Great question! Unfortunately the answer is no. Shimano changed the spline depth on the x100 series. Therefore you would need a XT 8100 specific power meter such as the Stages Shimano XT M8100/8120 Power Meter or the power2max Shimano MTB Power Meter.
We have a separate article that explains all of your XT 8100 options: What power meter will fit my Shimano XT MTB crankset?